<html xmlns:v="urn:schemas-microsoft-com:vml"
xmlns:o="urn:schemas-microsoft-com:office:office"
xmlns:w="urn:schemas-microsoft-com:office:word"
xmlns:x="urn:schemas-microsoft-com:office:excel"
xmlns:m="http://schemas.microsoft.com/office/2004/12/omml"
xmlns="http://www.w3.org/TR/REC-html40">

<head>
<meta http-equiv=Content-Type content="text/html; charset=gb2312">
<meta name=ProgId content=Word.Document>
<meta name=Generator content="Microsoft Word 12">
<meta name=Originator content="Microsoft Word 12">
<link rel=File-List href="sampleCluster.files/filelist.xml">
<link rel=Edit-Time-Data href="sampleCluster.files/editdata.mso">
<!--[if !mso]>
<style>
v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style>
<![endif]--><!--[if gte mso 9]><xml>
 <o:DocumentProperties>
  <o:Author>Administrator</o:Author>
  <o:LastAuthor>zequn zheng</o:LastAuthor>
  <o:Revision>20</o:Revision>
  <o:TotalTime>210</o:TotalTime>
  <o:Created>2016-09-13T09:11:00Z</o:Created>
  <o:LastSaved>2019-07-05T07:13:00Z</o:LastSaved>
  <o:Pages>1</o:Pages>
  <o:Words>234</o:Words>
  <o:Characters>1337</o:Characters>
  <o:Company>china</o:Company>
  <o:Lines>11</o:Lines>
  <o:Paragraphs>3</o:Paragraphs>
  <o:CharactersWithSpaces>1568</o:CharactersWithSpaces>
  <o:Version>12.00</o:Version>
 </o:DocumentProperties>
</xml><![endif]-->
<link rel=themeData href="sampleCluster.files/themedata.thmx">
<link rel=colorSchemeMapping href="sampleCluster.files/colorschememapping.xml">
<!--[if gte mso 9]><xml>
 <w:WordDocument>
  <w:Zoom>98</w:Zoom>
  <w:SpellingState>Clean</w:SpellingState>
  <w:GrammarState>Clean</w:GrammarState>
  <w:TrackMoves>false</w:TrackMoves>
  <w:TrackFormatting/>
  <w:PunctuationKerning/>
  <w:DrawingGridVerticalSpacing>7.8 磅</w:DrawingGridVerticalSpacing>
  <w:DisplayHorizontalDrawingGridEvery>0</w:DisplayHorizontalDrawingGridEvery>
  <w:DisplayVerticalDrawingGridEvery>2</w:DisplayVerticalDrawingGridEvery>
  <w:ValidateAgainstSchemas/>
  <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid>
  <w:IgnoreMixedContent>false</w:IgnoreMixedContent>
  <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText>
  <w:DoNotPromoteQF/>
  <w:LidThemeOther>EN-US</w:LidThemeOther>
  <w:LidThemeAsian>ZH-CN</w:LidThemeAsian>
  <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript>
  <w:Compatibility>
   <w:SpaceForUL/>
   <w:BalanceSingleByteDoubleByteWidth/>
   <w:DoNotLeaveBackslashAlone/>
   <w:ULTrailSpace/>
   <w:DoNotExpandShiftReturn/>
   <w:AdjustLineHeightInTable/>
   <w:BreakWrappedTables/>
   <w:SnapToGridInCell/>
   <w:WrapTextWithPunct/>
   <w:UseAsianBreakRules/>
   <w:DontGrowAutofit/>
   <w:SplitPgBreakAndParaMark/>
   <w:DontVertAlignCellWithSp/>
   <w:DontBreakConstrainedForcedTables/>
   <w:DontVertAlignInTxbx/>
   <w:Word11KerningPairs/>
   <w:CachedColBalance/>
   <w:UseFELayout/>
  </w:Compatibility>
  <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel>
  <m:mathPr>
   <m:mathFont m:val="Cambria Math"/>
   <m:brkBin m:val="before"/>
   <m:brkBinSub m:val="&#45;-"/>
   <m:smallFrac m:val="off"/>
   <m:dispDef/>
   <m:lMargin m:val="0"/>
   <m:rMargin m:val="0"/>
   <m:defJc m:val="centerGroup"/>
   <m:wrapIndent m:val="1440"/>
   <m:intLim m:val="subSup"/>
   <m:naryLim m:val="undOvr"/>
  </m:mathPr></w:WordDocument>
</xml><![endif]--><!--[if gte mso 9]><xml>
 <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
  DefSemiHidden="true" DefQFormat="false" DefPriority="99"
  LatentStyleCount="267">
  <w:LsdException Locked="false" Priority="0" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Normal"/>
  <w:LsdException Locked="false" Priority="9" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="heading 1"/>
  <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2"/>
  <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3"/>
  <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 4"/>
  <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 5"/>
  <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 6"/>
  <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 7"/>
  <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 8"/>
  <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 9"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 1"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 2"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 3"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 4"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 5"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 6"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 7"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 8"/>
  <w:LsdException Locked="false" Priority="39" Name="toc 9"/>
  <w:LsdException Locked="false" Priority="35" QFormat="true" Name="caption"/>
  <w:LsdException Locked="false" Priority="10" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Title"/>
  <w:LsdException Locked="false" Priority="1" Name="Default Paragraph Font"/>
  <w:LsdException Locked="false" Priority="11" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Subtitle"/>
  <w:LsdException Locked="false" Priority="22" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Strong"/>
  <w:LsdException Locked="false" Priority="20" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Emphasis"/>
  <w:LsdException Locked="false" Priority="59" SemiHidden="false"
   UnhideWhenUsed="false" Name="Table Grid"/>
  <w:LsdException Locked="false" UnhideWhenUsed="false" Name="Placeholder Text"/>
  <w:LsdException Locked="false" Priority="1" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="No Spacing"/>
  <w:LsdException Locked="false" Priority="60" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Shading"/>
  <w:LsdException Locked="false" Priority="61" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light List"/>
  <w:LsdException Locked="false" Priority="62" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Grid"/>
  <w:LsdException Locked="false" Priority="63" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 1"/>
  <w:LsdException Locked="false" Priority="64" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 2"/>
  <w:LsdException Locked="false" Priority="65" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 1"/>
  <w:LsdException Locked="false" Priority="66" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 2"/>
  <w:LsdException Locked="false" Priority="67" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 1"/>
  <w:LsdException Locked="false" Priority="68" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 2"/>
  <w:LsdException Locked="false" Priority="69" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 3"/>
  <w:LsdException Locked="false" Priority="70" SemiHidden="false"
   UnhideWhenUsed="false" Name="Dark List"/>
  <w:LsdException Locked="false" Priority="71" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Shading"/>
  <w:LsdException Locked="false" Priority="72" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful List"/>
  <w:LsdException Locked="false" Priority="73" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Grid"/>
  <w:LsdException Locked="false" Priority="60" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Shading Accent 1"/>
  <w:LsdException Locked="false" Priority="61" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light List Accent 1"/>
  <w:LsdException Locked="false" Priority="62" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Grid Accent 1"/>
  <w:LsdException Locked="false" Priority="63" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 1 Accent 1"/>
  <w:LsdException Locked="false" Priority="64" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 2 Accent 1"/>
  <w:LsdException Locked="false" Priority="65" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 1 Accent 1"/>
  <w:LsdException Locked="false" UnhideWhenUsed="false" Name="Revision"/>
  <w:LsdException Locked="false" Priority="34" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="List Paragraph"/>
  <w:LsdException Locked="false" Priority="29" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Quote"/>
  <w:LsdException Locked="false" Priority="30" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Intense Quote"/>
  <w:LsdException Locked="false" Priority="66" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 2 Accent 1"/>
  <w:LsdException Locked="false" Priority="67" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 1 Accent 1"/>
  <w:LsdException Locked="false" Priority="68" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 2 Accent 1"/>
  <w:LsdException Locked="false" Priority="69" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 3 Accent 1"/>
  <w:LsdException Locked="false" Priority="70" SemiHidden="false"
   UnhideWhenUsed="false" Name="Dark List Accent 1"/>
  <w:LsdException Locked="false" Priority="71" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Shading Accent 1"/>
  <w:LsdException Locked="false" Priority="72" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful List Accent 1"/>
  <w:LsdException Locked="false" Priority="73" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Grid Accent 1"/>
  <w:LsdException Locked="false" Priority="60" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Shading Accent 2"/>
  <w:LsdException Locked="false" Priority="61" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light List Accent 2"/>
  <w:LsdException Locked="false" Priority="62" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Grid Accent 2"/>
  <w:LsdException Locked="false" Priority="63" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 1 Accent 2"/>
  <w:LsdException Locked="false" Priority="64" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 2 Accent 2"/>
  <w:LsdException Locked="false" Priority="65" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 1 Accent 2"/>
  <w:LsdException Locked="false" Priority="66" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 2 Accent 2"/>
  <w:LsdException Locked="false" Priority="67" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 1 Accent 2"/>
  <w:LsdException Locked="false" Priority="68" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 2 Accent 2"/>
  <w:LsdException Locked="false" Priority="69" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 3 Accent 2"/>
  <w:LsdException Locked="false" Priority="70" SemiHidden="false"
   UnhideWhenUsed="false" Name="Dark List Accent 2"/>
  <w:LsdException Locked="false" Priority="71" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Shading Accent 2"/>
  <w:LsdException Locked="false" Priority="72" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful List Accent 2"/>
  <w:LsdException Locked="false" Priority="73" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Grid Accent 2"/>
  <w:LsdException Locked="false" Priority="60" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Shading Accent 3"/>
  <w:LsdException Locked="false" Priority="61" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light List Accent 3"/>
  <w:LsdException Locked="false" Priority="62" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Grid Accent 3"/>
  <w:LsdException Locked="false" Priority="63" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 1 Accent 3"/>
  <w:LsdException Locked="false" Priority="64" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 2 Accent 3"/>
  <w:LsdException Locked="false" Priority="65" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 1 Accent 3"/>
  <w:LsdException Locked="false" Priority="66" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 2 Accent 3"/>
  <w:LsdException Locked="false" Priority="67" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 1 Accent 3"/>
  <w:LsdException Locked="false" Priority="68" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 2 Accent 3"/>
  <w:LsdException Locked="false" Priority="69" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 3 Accent 3"/>
  <w:LsdException Locked="false" Priority="70" SemiHidden="false"
   UnhideWhenUsed="false" Name="Dark List Accent 3"/>
  <w:LsdException Locked="false" Priority="71" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Shading Accent 3"/>
  <w:LsdException Locked="false" Priority="72" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful List Accent 3"/>
  <w:LsdException Locked="false" Priority="73" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Grid Accent 3"/>
  <w:LsdException Locked="false" Priority="60" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Shading Accent 4"/>
  <w:LsdException Locked="false" Priority="61" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light List Accent 4"/>
  <w:LsdException Locked="false" Priority="62" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Grid Accent 4"/>
  <w:LsdException Locked="false" Priority="63" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 1 Accent 4"/>
  <w:LsdException Locked="false" Priority="64" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 2 Accent 4"/>
  <w:LsdException Locked="false" Priority="65" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 1 Accent 4"/>
  <w:LsdException Locked="false" Priority="66" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 2 Accent 4"/>
  <w:LsdException Locked="false" Priority="67" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 1 Accent 4"/>
  <w:LsdException Locked="false" Priority="68" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 2 Accent 4"/>
  <w:LsdException Locked="false" Priority="69" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 3 Accent 4"/>
  <w:LsdException Locked="false" Priority="70" SemiHidden="false"
   UnhideWhenUsed="false" Name="Dark List Accent 4"/>
  <w:LsdException Locked="false" Priority="71" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Shading Accent 4"/>
  <w:LsdException Locked="false" Priority="72" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful List Accent 4"/>
  <w:LsdException Locked="false" Priority="73" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Grid Accent 4"/>
  <w:LsdException Locked="false" Priority="60" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Shading Accent 5"/>
  <w:LsdException Locked="false" Priority="61" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light List Accent 5"/>
  <w:LsdException Locked="false" Priority="62" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Grid Accent 5"/>
  <w:LsdException Locked="false" Priority="63" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 1 Accent 5"/>
  <w:LsdException Locked="false" Priority="64" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 2 Accent 5"/>
  <w:LsdException Locked="false" Priority="65" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 1 Accent 5"/>
  <w:LsdException Locked="false" Priority="66" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 2 Accent 5"/>
  <w:LsdException Locked="false" Priority="67" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 1 Accent 5"/>
  <w:LsdException Locked="false" Priority="68" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 2 Accent 5"/>
  <w:LsdException Locked="false" Priority="69" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 3 Accent 5"/>
  <w:LsdException Locked="false" Priority="70" SemiHidden="false"
   UnhideWhenUsed="false" Name="Dark List Accent 5"/>
  <w:LsdException Locked="false" Priority="71" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Shading Accent 5"/>
  <w:LsdException Locked="false" Priority="72" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful List Accent 5"/>
  <w:LsdException Locked="false" Priority="73" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Grid Accent 5"/>
  <w:LsdException Locked="false" Priority="60" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Shading Accent 6"/>
  <w:LsdException Locked="false" Priority="61" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light List Accent 6"/>
  <w:LsdException Locked="false" Priority="62" SemiHidden="false"
   UnhideWhenUsed="false" Name="Light Grid Accent 6"/>
  <w:LsdException Locked="false" Priority="63" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 1 Accent 6"/>
  <w:LsdException Locked="false" Priority="64" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Shading 2 Accent 6"/>
  <w:LsdException Locked="false" Priority="65" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 1 Accent 6"/>
  <w:LsdException Locked="false" Priority="66" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium List 2 Accent 6"/>
  <w:LsdException Locked="false" Priority="67" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 1 Accent 6"/>
  <w:LsdException Locked="false" Priority="68" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 2 Accent 6"/>
  <w:LsdException Locked="false" Priority="69" SemiHidden="false"
   UnhideWhenUsed="false" Name="Medium Grid 3 Accent 6"/>
  <w:LsdException Locked="false" Priority="70" SemiHidden="false"
   UnhideWhenUsed="false" Name="Dark List Accent 6"/>
  <w:LsdException Locked="false" Priority="71" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Shading Accent 6"/>
  <w:LsdException Locked="false" Priority="72" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful List Accent 6"/>
  <w:LsdException Locked="false" Priority="73" SemiHidden="false"
   UnhideWhenUsed="false" Name="Colorful Grid Accent 6"/>
  <w:LsdException Locked="false" Priority="19" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Subtle Emphasis"/>
  <w:LsdException Locked="false" Priority="21" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Intense Emphasis"/>
  <w:LsdException Locked="false" Priority="31" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Subtle Reference"/>
  <w:LsdException Locked="false" Priority="32" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Intense Reference"/>
  <w:LsdException Locked="false" Priority="33" SemiHidden="false"
   UnhideWhenUsed="false" QFormat="true" Name="Book Title"/>
  <w:LsdException Locked="false" Priority="37" Name="Bibliography"/>
  <w:LsdException Locked="false" Priority="39" QFormat="true" Name="TOC Heading"/>
 </w:LatentStyles>
</xml><![endif]-->
<style>
<!--
 /* Font Definitions */
 @font-face
	{font-family:宋体;
	panose-1:2 1 6 0 3 1 1 1 1 1;
	mso-font-alt:SimSun;
	mso-font-charset:134;
	mso-generic-font-family:auto;
	mso-font-pitch:variable;
	mso-font-signature:3 680460288 22 0 262145 0;}
@font-face
	{font-family:"Cambria Math";
	panose-1:2 4 5 3 5 4 6 3 2 4;
	mso-font-charset:1;
	mso-generic-font-family:roman;
	mso-font-format:other;
	mso-font-pitch:variable;
	mso-font-signature:0 0 0 0 0 0;}
@font-face
	{font-family:微软雅黑;
	panose-1:2 11 5 3 2 2 4 2 2 4;
	mso-font-charset:134;
	mso-generic-font-family:swiss;
	mso-font-pitch:variable;
	mso-font-signature:-2147483001 718224464 22 0 262175 0;}
@font-face
	{font-family:"\@微软雅黑";
	panose-1:2 11 5 3 2 2 4 2 2 4;
	mso-font-charset:134;
	mso-generic-font-family:swiss;
	mso-font-pitch:variable;
	mso-font-signature:-2147483001 684670032 22 0 262175 0;}
@font-face
	{font-family:"\@宋体";
	panose-1:2 1 6 0 3 1 1 1 1 1;
	mso-font-charset:134;
	mso-generic-font-family:auto;
	mso-font-pitch:variable;
	mso-font-signature:3 680460288 22 0 262145 0;}
 /* Style Definitions */
 p.MsoNormal, li.MsoNormal, div.MsoNormal
	{mso-style-unhide:no;
	mso-style-qformat:yes;
	mso-style-parent:"";
	margin:0cm;
	margin-bottom:.0001pt;
	text-align:justify;
	text-justify:inter-ideograph;
	mso-pagination:none;
	font-size:10.0pt;
	font-family:"Times New Roman","serif";
	mso-fareast-font-family:宋体;
	mso-fareast-theme-font:minor-fareast;}
p.MsoHeader, li.MsoHeader, div.MsoHeader
	{mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-link:"页眉 Char";
	margin:0cm;
	margin-bottom:.0001pt;
	text-align:center;
	mso-pagination:none;
	tab-stops:center 207.65pt right 415.3pt;
	layout-grid-mode:char;
	border:none;
	mso-border-bottom-alt:solid windowtext .75pt;
	padding:0cm;
	mso-padding-alt:0cm 0cm 1.0pt 0cm;
	font-size:9.0pt;
	font-family:"Times New Roman","serif";
	mso-fareast-font-family:宋体;
	mso-fareast-theme-font:minor-fareast;}
p.MsoFooter, li.MsoFooter, div.MsoFooter
	{mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-link:"页脚 Char";
	margin:0cm;
	margin-bottom:.0001pt;
	mso-pagination:none;
	tab-stops:center 207.65pt right 415.3pt;
	layout-grid-mode:char;
	font-size:9.0pt;
	font-family:"Times New Roman","serif";
	mso-fareast-font-family:宋体;
	mso-fareast-theme-font:minor-fareast;}
p.MsoPlainText, li.MsoPlainText, div.MsoPlainText
	{mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-link:"纯文本 Char";
	margin:0cm;
	margin-bottom:.0001pt;
	text-align:justify;
	text-justify:inter-ideograph;
	mso-pagination:none;
	font-size:10.0pt;
	mso-bidi-font-size:10.5pt;
	font-family:宋体;
	mso-hansi-font-family:"Courier New";
	mso-bidi-font-family:"Courier New";}
p.MsoAcetate, li.MsoAcetate, div.MsoAcetate
	{mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-link:"批注框文本 Char";
	margin:0cm;
	margin-bottom:.0001pt;
	text-align:justify;
	text-justify:inter-ideograph;
	mso-pagination:none;
	font-size:9.0pt;
	font-family:"Times New Roman","serif";
	mso-fareast-font-family:宋体;
	mso-fareast-theme-font:minor-fareast;}
span.Char
	{mso-style-name:"页眉 Char";
	mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-unhide:no;
	mso-style-locked:yes;
	mso-style-link:页眉;
	mso-ansi-font-size:9.0pt;
	mso-bidi-font-size:9.0pt;}
span.Char0
	{mso-style-name:"页脚 Char";
	mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-unhide:no;
	mso-style-locked:yes;
	mso-style-link:页脚;
	mso-ansi-font-size:9.0pt;
	mso-bidi-font-size:9.0pt;}
span.Char1
	{mso-style-name:"纯文本 Char";
	mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-unhide:no;
	mso-style-locked:yes;
	mso-style-link:纯文本;
	mso-bidi-font-size:10.5pt;
	font-family:宋体;
	mso-ascii-font-family:宋体;
	mso-fareast-font-family:宋体;
	mso-hansi-font-family:"Courier New";
	mso-bidi-font-family:"Courier New";}
span.Char2
	{mso-style-name:"批注框文本 Char";
	mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-unhide:no;
	mso-style-locked:yes;
	mso-style-link:批注框文本;
	mso-ansi-font-size:9.0pt;
	mso-bidi-font-size:9.0pt;
	font-family:"Times New Roman","serif";
	mso-ascii-font-family:"Times New Roman";
	mso-hansi-font-family:"Times New Roman";
	mso-bidi-font-family:"Times New Roman";}
span.SpellE
	{mso-style-name:"";
	mso-spl-e:yes;}
.MsoChpDefault
	{mso-style-type:export-only;
	mso-default-props:yes;
	font-size:10.0pt;
	mso-ansi-font-size:10.0pt;
	mso-bidi-font-size:10.0pt;
	mso-ascii-font-family:"Times New Roman";
	mso-hansi-font-family:"Times New Roman";
	mso-bidi-font-family:"Times New Roman";
	mso-bidi-theme-font:minor-bidi;
	mso-font-kerning:0pt;}
 /* Page Definitions */
 @page
	{mso-page-border-surround-header:no;
	mso-page-border-surround-footer:no;
	mso-footnote-separator:url("sampleCluster.files/header.html") fs;
	mso-footnote-continuation-separator:url("sampleCluster.files/header.html") fcs;
	mso-endnote-separator:url("sampleCluster.files/header.html") es;
	mso-endnote-continuation-separator:url("sampleCluster.files/header.html") ecs;}
@page WordSection1
	{size:595.3pt 841.9pt;
	margin:72.0pt 90.0pt 72.0pt 90.0pt;
	mso-header-margin:42.55pt;
	mso-footer-margin:49.6pt;
	mso-paper-source:0;
	layout-grid:15.6pt;}
div.WordSection1
	{page:WordSection1;}
-->
</style>
<!--[if gte mso 10]>
<style>
 /* Style Definitions */
 table.MsoNormalTable
	{mso-style-name:普通表格;
	mso-tstyle-rowband-size:0;
	mso-tstyle-colband-size:0;
	mso-style-noshow:yes;
	mso-style-priority:99;
	mso-style-qformat:yes;
	mso-style-parent:"";
	mso-padding-alt:0cm 5.4pt 0cm 5.4pt;
	mso-para-margin:0cm;
	mso-para-margin-bottom:.0001pt;
	mso-pagination:widow-orphan;
	font-size:10.0pt;
	font-family:"Times New Roman","serif";
	mso-bidi-font-family:"Times New Roman";
	mso-bidi-theme-font:minor-bidi;}
table.MsoTableGrid
	{mso-style-name:网格型;
	mso-tstyle-rowband-size:0;
	mso-tstyle-colband-size:0;
	mso-style-priority:59;
	mso-style-unhide:no;
	border:solid windowtext 1.0pt;
	mso-border-alt:solid windowtext .5pt;
	mso-padding-alt:0cm 5.4pt 0cm 5.4pt;
	mso-border-insideh:.5pt solid windowtext;
	mso-border-insidev:.5pt solid windowtext;
	mso-para-margin:0cm;
	mso-para-margin-bottom:.0001pt;
	mso-pagination:widow-orphan;
	font-size:10.0pt;
	font-family:"Times New Roman","serif";
	mso-bidi-font-family:"Times New Roman";
	mso-bidi-theme-font:minor-bidi;}
</style>
<![endif]--><!--[if gte mso 9]><xml>
 <o:shapedefaults v:ext="edit" spidmax="15362"/>
</xml><![endif]--><!--[if gte mso 9]><xml>
 <o:shapelayout v:ext="edit">
  <o:idmap v:ext="edit" data="2"/>
 </o:shapelayout></xml><![endif]-->
</head>

<body lang=ZH-CN style='tab-interval:21.0pt;text-justify-trim:punctuation'>

<div class=WordSection1 style='layout-grid:15.6pt'>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>分析模块，输入差异基因表达量矩阵（如，差异基因</span><span class=SpellE><span lang=EN-US
style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;mso-font-kerning:
1.0pt'>fpkm</span></span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'>/<span class=SpellE>tpm</span></span><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>矩阵）。绘制样本聚类树，用于查看是否存在明显的离群样本。</span><span lang=EN-US style='mso-bidi-font-size:
12.0pt;mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>当然，离群样本，也可通过</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'>PCA</span><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>分析的作图结果进行判断。</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>判断出离群样本后，在进行后续的</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'>WGCNA</span><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>分析之前，需要对输入的表达量矩阵进行离群样本的删除，即删除对应样本列的数据。</span><span lang=EN-US
style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;mso-font-kerning:
1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>可应用分析模块“</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'>Get a sub-Matrix</span><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>”，进行相应离群样本列数据的删除。建议参考，分析模块“</span><span lang=EN-US style='mso-bidi-font-size:
12.0pt;mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'>Get a sub-Matrix</span><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>”的帮助文档进行操作。</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>分析模块，使用了</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'>R</span><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>语言的</span><span class=SpellE><span lang=EN-US style='mso-bidi-font-size:
12.0pt;mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'>flashClust</span></span><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>包。</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:
微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt'>WGCNA</span><span style='mso-bidi-font-size:12.0pt;
font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman";mso-font-kerning:1.0pt'>分析需要不少于</span><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt'>15</span><span style='mso-bidi-font-size:12.0pt;
font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman";mso-font-kerning:1.0pt'>个样品的表达量数据，这样结果才具有统计意义。</span><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><b
style='mso-bidi-font-weight:normal'><span style='mso-bidi-font-size:12.0pt;
font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman";mso-font-kerning:1.0pt'>输入：</span></b><b
style='mso-bidi-font-weight:normal'><span lang=EN-US style='mso-bidi-font-size:
12.0pt;mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></b></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>差异基因表达量矩阵（如，差异基因</span><span class=SpellE><span lang=EN-US
style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;mso-font-kerning:
1.0pt'>fpkm</span></span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'>/<span class=SpellE>tpm</span></span><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>矩阵）。</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:
微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>示例：</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:
微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<table class=MsoTableGrid border=0 cellspacing=0 cellpadding=0
 style='margin-left:19.85pt;border-collapse:collapse;mso-table-layout-alt:fixed;
 border:none;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 0cm;
 mso-border-insideh:none;mso-border-insidev:none'>
 <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;height:14.95pt'>
  <td width=125 valign=top style='width:93.55pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'></td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>T4<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>T5<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>T6<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>T7<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>T8<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>T9<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style='mso-yfti-irow:1;height:14.95pt'>
  <td width=125 valign=top style='width:93.55pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>BM590_A0004<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>406.46<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>494.13<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>414.62<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>825.09<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>2678.41<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>555.67<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style='mso-yfti-irow:2;height:14.95pt'>
  <td width=125 valign=top style='width:93.55pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>BM590_A0005<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>605.70<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>755.09<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>643.55<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>1184.73<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>2980.14<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>568.58<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style='mso-yfti-irow:3;height:15.0pt'>
  <td width=125 valign=top style='width:93.55pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>BM590_A0015<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>382.41<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>435.68<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>435.09<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>667.24<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>1664.78<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>511.53<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style='mso-yfti-irow:4;height:14.95pt'>
  <td width=125 valign=top style='width:93.55pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>BM590_A0021<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>305.80<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>347.07<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>323.75<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>151.16<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>57.04<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>252.18<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style='mso-yfti-irow:5;height:14.95pt'>
  <td width=125 valign=top style='width:93.55pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>BM590_A0025<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>82.60<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>71.30<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>83.22<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>95.78<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>311.02<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:14.95pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>96.31<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style='mso-yfti-irow:6;height:15.0pt'>
  <td width=125 valign=top style='width:93.55pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>BM590_A0028<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>389.64<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>441.62<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>387.26<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>1020.02<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>5531.28<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>345.31<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style='mso-yfti-irow:7;mso-yfti-lastrow:yes;height:15.0pt'>
  <td width=125 valign=top style='width:93.55pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>BM590_A0046<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>295.72<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>291.23<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>379.24<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>308.84<o:p></o:p></span></p>
  </td>
  <td width=85 valign=top style='width:63.8pt;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>92.26<o:p></o:p></span></p>
  </td>
  <td width=76 valign=top style='width:2.0cm;padding:0cm 5.4pt 0cm 0cm;
  height:15.0pt'>
  <p class=MsoNormal><span lang=EN-US style='mso-fareast-font-family:微软雅黑'>517.02<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><b
style='mso-bidi-font-weight:normal'><span style='mso-bidi-font-size:12.0pt;
font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman";mso-font-kerning:1.0pt'>输出：</span></b><b
style='mso-bidi-font-weight:normal'><span lang=EN-US style='mso-bidi-font-size:
12.0pt;mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></b></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>样品层次聚类树状图</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;
mso-fareast-font-family:微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
style='mso-bidi-font-size:12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman";mso-font-kerning:
1.0pt'>示例：</span><span lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:
微软雅黑;mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:20.0pt;mso-char-indent-count:2.0'><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt;mso-no-proof:yes'><!--[if gte vml 1]><v:shapetype id="_x0000_t75"
 coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe"
 filled="f" stroked="f">
 <v:stroke joinstyle="miter"/>
 <v:formulas>
  <v:f eqn="if lineDrawn pixelLineWidth 0"/>
  <v:f eqn="sum @0 1 0"/>
  <v:f eqn="sum 0 0 @1"/>
  <v:f eqn="prod @2 1 2"/>
  <v:f eqn="prod @3 21600 pixelWidth"/>
  <v:f eqn="prod @3 21600 pixelHeight"/>
  <v:f eqn="sum @0 0 1"/>
  <v:f eqn="prod @6 1 2"/>
  <v:f eqn="prod @7 21600 pixelWidth"/>
  <v:f eqn="sum @8 21600 0"/>
  <v:f eqn="prod @7 21600 pixelHeight"/>
  <v:f eqn="sum @10 21600 0"/>
 </v:formulas>
 <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/>
 <o:lock v:ext="edit" aspectratio="t"/>
</v:shapetype><v:shape id="图片_x0020_4" o:spid="_x0000_i1025" type="#_x0000_t75"
 style='width:365.25pt;height:273.75pt;visibility:visible;mso-wrap-style:square'>
 <v:imagedata src="sampleCluster.files/image001.png" o:title=""/>
</v:shape><![endif]--><![if !vml]><img width=487 height=365
src="sampleCluster.files/image002.jpg" v:shapes="图片_x0020_4"><![endif]></span><span
lang=EN-US style='mso-bidi-font-size:12.0pt;mso-fareast-font-family:微软雅黑;
mso-font-kerning:1.0pt'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span style='mso-bidi-font-size:
12.0pt;font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman";mso-font-kerning:1.0pt'>可</span><span
style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman"'>通过层次聚类树状图进行离群样本的判断。如上图所示，</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'>T8</span><span
style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman"'>很有可能是一个离群样本。在后续的数据分析中，需要先在表达量矩阵中，删除对应的离群样本数据。当然，可进行</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'>PCA</span><span
style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman"'>作图分析，进行离群样本的进一步确认。</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span style='font-family:"微软雅黑","sans-serif";
mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:"Times New Roman"'>分析模块引用了</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'>R</span><span style='font-family:
"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:
"Times New Roman"'>语言（</span><span lang=EN-US style='mso-fareast-font-family:
微软雅黑'>v3.3.0</span><span style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman"'>）</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'>flashClust</span><span
style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman"'>包（</span><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'>v1.01-2</span><span style='font-family:
"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:
"Times New Roman"'>）中的</span><span lang=EN-US style='mso-fareast-font-family:
微软雅黑'>flashClust</span><span style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:
"Times New Roman";mso-hansi-font-family:"Times New Roman"'>函数进行聚类和构树（</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'>https://cran.r-project.org/web/packages/flashClust/index.html</span><span
style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman"'>）。</span><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span style='font-family:"微软雅黑","sans-serif";
mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:"Times New Roman"'>其中，</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'>the distance measure is</span><span
style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman"'>“</span><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'>euclidean</span><span style='font-family:
"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:
"Times New Roman"'>”，</span><span lang=EN-US style='mso-fareast-font-family:
微软雅黑'>the agglomeration method is</span><span style='font-family:"微软雅黑","sans-serif";
mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:"Times New Roman"'>“</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'>average</span><span
style='font-family:"微软雅黑","sans-serif";mso-ascii-font-family:"Times New Roman";
mso-hansi-font-family:"Times New Roman"'>”，即两点的距离为欧式距离，集合之间的距离为类平均法。</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span style='font-family:"微软雅黑","sans-serif";
mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:"Times New Roman"'>相关文献如下所示：</span><span
lang=EN-US style='mso-fareast-font-family:微软雅黑'><o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'>[1] Langfelder P, Horvath S (2008) WGCNA:
an R package for weighted correlation network analysis. BMC Bioinformatics
2008, 9:559. <o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'>[2] Langfelder P, Horvath S (2007)
Eigengene networks for studying the relationships between co-expression
modules. BMC Systems Biology 2007, 1:54.<o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'>[3] Bin Zhang and Steve Horvath (2005)
&quot;A General Framework for Weighted Gene Co-Expression Network
Analysis&quot;, Statistical Applications in Genetics and Molecular Biology:
Vol. 4: No. 1, Article 17.<o:p></o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal style='text-indent:21.0pt'><span lang=EN-US
style='mso-fareast-font-family:微软雅黑'><o:p>&nbsp;</o:p></span></p>

</div>

</body>

</html>
